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Of note, the IGF-IR downstream effectors Akt and mTOR promote the repair of radiation-induced DNA double strand breaks and confer resistance to radiotherapy [93, 94]

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Yes, GLP-1 medications were originally developed for type 2 diabetes and can help manage blood sugar while promoting weight loss

The NIHR 'Be Part of Research' portal and ClinicalTrials.gov list current recruitment opportunities for investigational obesity studies

(131) proved the neuroprotective efficacy of intracerebroventricular injection (i.c.v.) of Ex-4 exerted after transient ischemia/reperfusion in rats and first suggested that Ex-4 played a neuroprotective role probably by stimulating the GLP-1R/-endorphin signal pathway in hippocampal microglia (76)

This is particularly relevant for lupus patients, who are often women of reproductive age